Wednesday, May 6, 2020
Special Education Essay Free Essays
To efficaciously speak about the consequence of IDââ¬â¢s in the schoolroom I thought who better to speak to than a instructor that has a schoolroom full of ID pupils. Ms. Tornetta Clark. We will write a custom essay sample on Special Education Essay or any similar topic only for you Order Now she is an Intervention Specialist in a SED room for classs 1-4 depending upon age. We began our conversation with what lead her to go an Intervention Specialist? Ms. Clark stated that she had ever wanted to be a teacher even as a kid. so when she went to college she decided to go a instructor she started as an simple instructor and subsequently decided to acquire into particular instruction. As clip went on she learned that she enjoyed these kids even more than the others. it was more sweet. So now that we have broken the ice so to talk can you state me what some of the jobs associated with measuring the kids with ID may be? Tornetta asked me which group of kids would I wish to discourse. the culturally diverse. gender particular. the psychological these are all type of ID kids and different types of appraisals. so where would you like to get down? I thought that it would be best for her to state me about the most hard one and she choose culturally diverse pupils. Ms. Clark states that when covering with the minorities there are extra beds of complexness to see particularly if the kid is of another ethnicity than the individual that is making the appraisal. Ms. Clark besides states that she prefers to make the bulk of her appraisals on her ain merely because she has been making this for a long clip and that she has worked with several different ethnicities. Having worked with the different ethnicities I have the upper manus and a kid can experience when they are understood or when person is pacifying them. In my many old ages of learning I have besides realized that kids can experience when person truly understands them and attentions. In my schoolroom we start the forenoon off by stating good forenoon to everyone by name and so we each can remain one thing that happened last dark or over the weekend or merely something that they may desire to portion each kid gets two proceedingss and we have a timer to guarantee everyone acquire choice clip. This is besides something that works good on their societal accomplishments. Now every bit far as the appraisal on the psychological side most of these trial and appraisals are done in the clinic or with the healer. now there have been an juncture or two where I have sat in and I have even administered the appraisal. However the same jobs still exist these trial demand to be tailored to each kid and they are non they are standard which in my sentiment is pathetic each kid is different so each kid should be tested otherwise. Now I asked about gender specific proving but I have merely ran across that twice in my many old ages of instruction. nevertheless it does be and as pedagogues we need to be able to cover with it and go on to tech and keep our categories. There are or at least it used to be several instructors that were homophobic and thought that school is no topographic point for a childââ¬â¢s sexual penchant to come out or even to be discussed. Now in the schools we see it mundane boys keeping custodies with other male childs and misss making the same so therefore it has to be addressed. it can non be slid under the rug any longer. This is something that as pedagogues we besides need to be able to cover with particularly in our SED categories. these child need more unfastened treatments so that they do experience that they are being included. Our kids have a inclination to acquire picked on and so they end up feeling as if no 1 understands them and they begin to contemplate self-destruction. as pedagogues it is our occupation to make our best to discourage those types of feelings and to promote a kid to be true to who they think they are and to non judge others for being different. We attempted to acquire back to the interview with on last inquiry and that was. what are the features of the teacherââ¬â¢s pupils with ID that consequence in eligibility for particular instruction? Ms. Clark informed that the bulk of the pupils that go through some kind of proving do non acquire into a particular instruction plan. However there are grounds for that in some instances it is because the parents do non force and maintain up with the assignments every bit good as follow through with what they need to make every bit far as information that may be needed to acquire a kid into a plan and doctorsââ¬â¢ assignments. the letterââ¬â¢s from the doctorââ¬â¢s. There are all kinds of grounds and so there are specific plans that some parents would wish to see their kid in. but there is a waiting list or there is another plan that is comparable but the parent is loath. Besides some parentââ¬â¢s may non desire their kid labeled as a particular instruction pupil so they are in denial. And last but non lest so there are the vicinity schools that are full and there are no exclusions to be made so that the kid can remain with their siblings. this besides goes into the transit kingdom of the jobs as good. some territories offer transit to kids but if there are siblings they can non have transit so parents do non desire their kids separated and that is undrstandbale in most instances. Clark tells me that she feels that if one kid attends the school in the particular instruction plan so the siblings should go to that school every bit good and they should have transit as good. This would likely maintain down some of the confusion on the coachs anyhow. particularly if there is an older sibling that can watch out for the younger 1s. This is how we were raised the oldest ever looked out for the younger 1s and made certain that everyone was home safe when ma and pa got in from work. I think that we need to acquire back to the slogan that it takes a small town to raise a kid and if we did so the school system and the communities would be a better topographic point. After speaking with Ms. Clark I thought about how I raised my kids and she was right when she said that it takes a small town to raise a kid. I was a individual parent for several old ages and I had six kids two were in the particular instruction plan at the vicinity school. I took them to school and my female parent picked them up from school. The neighbour watched them as they would come in the house and have snack a start their prep until I got place from work. I did the same for her on the weekends when she worked and she besides had a kid that was particular demands and we made it work if the school called and I was unable to travel she would travel and frailty versa. The point is that as parents and pedagogues we need to work together to allow our young person know that they are loved and that they are traveling to be taken attention of non merely in the schools but at place every bit good. Mentions Clark. Tornetta: Intervention Specialist. 2013 Personal conversation. June 20. How to cite Special Education Essay, Essay examples
Reason For Selection Of Nike Brand Samples â⬠MyAssignmenthelp.com
Question: Discuss about the Reason For Selection Of Nike Brand. Answer: I have chosen Nike, a global brand in manufacturing sports shoe for company selection. The four reasons for it are as follows: The first reason for selection is the unique brand personality of the company. It is global leader in making performance apparel and shoes and the company has great appeal among worlds leading athletes. Considering the huge target market that Nike has covered, it would be interesting to study the strategies they took to build their brand. The evidence by Aaker, (2015) suggests that brand personality like Nike can enhance brand loyalty and brand-customer relationship. Another positive business attributes of Nike is that it has also focused on innovation and development of their products. The evidence by Childs Jin, (2018) suggest that instead of basking on the glory of their high rated products, they have focused a lot on research and development to constantly evolve and provide innovative product range to consumers. Product quality and innovation is the main reason for Nike to dominate the sportswear market. The third reason for selecting Nike is the success of the company in its marketing activities. It has a distinctive brand image and advertising slogans that attracts target audience and the marketing strategy is also centered around brand image (Childs Jin, 2018). Hence, studying Nikes marketing mix would be interesting to learn about ways to promote product in market. The company is going to dominate the sportswear range for a long time because it has gone international and started stores in China and Latin America. Establishing stores in untapped market after analyzing demand for athletic apparel is likely to provide great business opportunities to the company (Childs Jin, 2018). The study by Childs Jin, (2018) is the evidence that clearly presents the innovative journey and evolution of Nike as a global leader in athletic wear. Reference: Aaker, D. (2015). Brand personalities are like snowflakes.Marketing News,49, available at: https://www.ama.org/publications/MarketingNews/Pages/brand-personalities-are-like-snowflakes.aspx?utm_content=bufferbdd17utm_medium=socialutm_source=plus.google.comutm_campaign=buffer Childs, M., Jin, B. (2018). Nike: An Innovation Journey. InProduct Innovation in the Global Fashion Industry(pp. 79-111). Palgrave Pivot, New York
Thursday, April 30, 2020
Positive Working Practice Essay Example
Positive Working Practice Paper Positive working practice enables health and social care workers to meet the specific needs of clients. Each area of work needs to ensure that it meets the needs of all individuals. This means that everyone must have access to all these services regardless of their abilities. Positive working practice becomes a great asset when considering how it can be applied to help those with additional needs. Before this was implemented, it was a common for individuals with additional needs to be expected to fit in with the rest of society. This meant that their needs were not being met. No real effort was put into concluding if the treatment they were receiving was beneficial to them or not. In recent years, this has been changed. Services provide a more patient orientated examination. Meaning the patient is directly involved in every decision made. This left all decisive action down to them, ensuring they got the treatment they needed and felt comfortable with. Looking at this from the perspective of someone with additional needs, you can conclude that this method would make them feel in control of their condition. Rather than someone telling what they think should be done, they decide. This is effective because after all, the individual is the one with the condition and not the service providers. They will have a better understanding of what will work for them and what will not. We will write a custom essay sample on Positive Working Practice specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Positive Working Practice specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Positive Working Practice specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Because of the more active role in the decision making process, individuals will have a better understanding of what will take place. This ensures people with additional needs are not being talked at; rather they are having an involved discussion with another person on equal terms. What if the individual is not mentally capable of making decisions regarding their wellbeing? How can health and social care providers provide services that meet the needs of clients that are not mentally capable of making decisions about their wellbeing? Decisions in such scenarios will be made by trusted family members or relatives. This ensures the decisions made have the interests of the client in mind. However, the Mental Capacity Act 2005 allows doctors to overrule decisions in certain scenarios. It can be disputed that this is marginalise those with mental conditions and will make the decisions made by relatives invalid. Although, you could also argue that these decisions are based on fear and a lack of medical knowledge, and not the needs of the individual. It is a difficult subject to consider and opinions will differ depending on the perspective. This largely depends on which model of disability is being considered. Relatives will try to take a more holistic approach, but will falter when trying to take into consideration medical aspects of the scenario. Such disputes are common because the service user will not be able to give their decisive opinion, leaving others to deduce what they believe is best for them. The implementation of Positive working practice is not limited to decision making. It also ensures that the services provided are readily available to everyone. This means that should someone decided on a particular service; it is guaranteed that they will be given access to this service. This can prove difficult for health care services to achieve. This is because individuals will have very different needs and views concerning what methods should be taken. Meaning that they will have to be as flexible as possible to ensure these needs are met. The purpose of positive working practice is not to overpower individuals and provide services they need to everyone. Rather it is implemented to ensure that services are readily available should anyone choose to use them. People working in health care are encouraged to provide care in a manner that assists clients as opposed to doing everything for them. This can be related to the care palliative patients receive. Care plans are assembled using the input of health professionals and family members. This allows the health care professionals to provide the medical care required, whilst doing so in an atmosphere that makes the client feel comfortable and dignified. Clients are also challenged to do what they are physically able unless they or family members have stated otherwise. It is common in health and medical areas of care for individuals to be treated using methods that promote normalisation. Applying my knowledge of positive working practice will prove beneficial when dealing with those with additional needs. It will enable me to provide care in a manner that respects the rights of the patients. Though my interaction with patients will be limited, I can still apply positive working practice into all aspects of care. This could include actions such as allowing wheelchair bound patients to transport themselves if they are able, not controlling it for them. I will also have to ensure I take a holistic approach to my treatment of patients. This is a method of that is learnt through experience and would not be something I could achieve without any prior experience. If I were to assume what could help a certain individual before I actually come into contact with them, I will not be implementing a needs-led approach to my care. Therefore, it is important that I apply my experiences into to future care so that I can make improvements when required.
Saturday, March 21, 2020
Clean Energy Importance
Clean Energy Importance Abstract Nowadays pollution is a tremendous problem for people and the earth. Researchers and scientists are trying so hard to try to solve that problem. Clean energy is one of the solutions. Clean energy means the energy that will not effect to the environment. Advertising We will write a custom research paper sample on Clean Energy Importance specifically for you for only $16.05 $11/page Learn More Clean energy is the energy that can produce by some of the existing resources, like from the wind or the sun. Many organizations try to use these resources to be the main energy for them. Despite the fact that clean energy costs more money than the other energy sources, it can give more benefits to organizations and to the world at large. Introduction No single energy solution can be able to meet the energy needs of the contemporary society. This explains why there are so many sources of energy. The society tries to utilize energy from various sources in a bid t o meet its energy needs. Currently, there are two major categories of energy: renewable and nons of clean energy There are numerous types of renewable energy sources, which are classified here as main types and other types of renewable energy. The main sources of clean energy contribute the highest numbers of Gig watts of clean energy to the worldââ¬â¢s energy market, while the other types of clean energy contribute negligible amounts of energy. Main types of clean energy Wind energy Wind energy is the energy generated after wind power turns wind turbines to generate electricity. Wind is a product of changes in the atmosphere. The changes in atmospheric temperatures and changes in atmospheric pressure create wind by making air to move around the earthââ¬â¢s surface. A wind turbine captures the wind power mechanically, and converts it into energy (Weir 1). Wind energy is therefore, a clean source of energy, and it can reliably meet the energy needs of the society. The energy i s cost-effective, affordable, sustainable, and pollution-free.Advertising We will write a custom research paper sample on Clean Energy Importance specifically for you for only $16.05 $11/page Learn More Since wind energy does not use fossil fuels, it does not produce toxic wastes, greenhouse gases, or radioactive wastes (Weir 1). This, therefore, implies that wind energy does not pollute the environment, and therefore, it is an effective way to fight global warming. Despite the reliability of wind energy for small-scale consumption, wind energy is inappropriate for large-scale consumption. This implies that it will be unwise to rely on wind energy in a factory. The reason for this is that wind energy is dependent on environmental changes, and thus there may be times when there is no wind to generate sufficient power. However, large-scale consumers of energy can counter this by having back-up power provision. That is, using wind energy as the main source of energy and another source like powerful back-up generators, which can be used when there is no enough wind to generate sufficient power. Wind-energy constitutes a small percentage (about 1%) of the worldââ¬â¢s energy generation (Weir 1). Solar energy There are several ways to generate energy from the sun. The most common is the solar panel. A solar panel or photovoltaic module captures sunlight and uses it to generate direct current electricity. The design of solar panel is such that it lasts for a long period (decades), while exposed to unfavourable conditions (Imboden 1). In addition to the solar panel, a photovoltaic cell (PV cell) can also harness solar energy. The photovoltaic cell (PV cell) uses sunlight to produce electricity. The PV cellââ¬â¢s body comprises of materials similar to those used in computer chips. These materials have the special property of releasing electrons upon exposure to sunlight, a property that makes them able to generate energy (Imboden 1). An other method of harnessing solar power is by using mirrors to concentrate it. The mirrors concentrate the solar power in one area, generating heat energy. The heat energy then produces electricity after powering a generator. Just like wind energy, solar energy is cheap, reliable and eco-friendly. Solar energy can therefore, be instrumental in countering global warming (Imboden 1). On the other hand, it is also dependent on environmental changes, and thus it is inappropriate for people who consume huge amounts of energy.Advertising Looking for research paper on environmental studies? Let's see if we can help you! Get your first paper with 15% OFF Learn More Biomass energy Biomass energy is organic waste and it is the oldest energy source because it was the primary source of energy until the nineteenth century. A large faction of human population for cooking and heating hitherto uses biomass energy. With technology advancement, it has been possible to transform the way biomass is used, and currently large biomass plants for generating power are in existence. Some coal plants have even converted from using coal to using biomass as their main raw material in order to reduce climate change and its effects. Biomass is carbons of such countries include India, China, etc. Hydro energy does not have emissions that contribute to global warming, and thus it is a reliable source of green energy. It does not have the disadvantages of intermittency and high costs associable with other clean energy sources. The main disadvantage of hydro energy is that it exposes an area to risks that can be catastrophic. It is thus apparent that the advantages of hydro energy outweigh its disadvantages. Other types of clean energy There are still other energy sources, which belong to the renewable energy category. Examples include tidal energy and wave energy. Tidal Energy Tidal energy is a small form of energy whose global capacity is about 500 MW. It, therefore, constitutes 0.001% of electricity generation worldwide (ââ¬Å"Renewable Energyâ⬠1). Numerous companies are however researching on ways through which they can develop tidal energy generation because it less costly and it does not pollute the environment. The current tidal energy success is attributable to the French Tidal Wave Power Plant. Wave Energy Wave energy is similar to tidal energy in terms of its capacity. It is, therefore, another niche source of green energy. The waves used in energy generation in this case are from the disturbance of the ocean by wind. In many regions, the wind blows consistently enough, forming continuous waves, which are reliable in energy gener ation. Wave-power devices then extract the energy carried by the waves from the water surface. Alternatively, the devices can extract the energy from fluctuations in pressure below the surface of the ocean. Some of the areas that are rich with oceanic waves that produce energy when harnessed with turbines include the western coasts of northern Canada, Australia, Southern Africa and Scotland (ââ¬Å"Renewable Energyâ⬠1). Some people even argue that nuclear energy is a renewable form of energy, but in the strict sense, the primary source of nuclear energy is non-renewable. Once a nuclear plant uses uranium fuel, the latter cannot be re-used. Conclusion As discussed above, the society has many choices as far as clean energy is concerned. It is, therefore, wise to choose renewable energy over its non-renewable counterparts in order to preserve our natural energy deposits for future generations, and limit the extent and effects of global warming. The use of renewable energy sourc es will also lead to minimal atmospheric levels of greenhouse gases, leading to a reduction of pollution. However, it is nearly impossible to reach a situation in which the world will be solely using renewable sources of energy to meet all its energy needs. It is, therefore, imperative that the society strikes a balance between the use of renewable and non-renewable energy. For instance, at home, people can use natural gas for functions like water heating, and they can use wind or solar energy used for other energy needs. From the discussion above, the main sources of clean energy include the sun, wind, water, biomass, and geothermal energy. In addition to these sources of clean energy, renewable and clean energy is also obtainable from oceanic waves and tides. The reason why the aforementioned sources of energy come under the other sources category is because the produce minimal amounts of energy, and thus they cannot be relied on for power production. They normally act as back-u ps for other sources of energy. For instance, tidal energy can back up nuclear energy. Imboden, Otis. ââ¬Å"Solar Energyâ⬠. National Geographic. 2011. Web. http://environment.nationalgeographic.com/environment/global-warming/solar-power-profile/ Klass, Donald. Biomass for Renewable Energy, Fuels, and Chemicals. New York 2010, Barnes Noble. Print. Renewable Energy. ââ¬Å"Types of Renewable Energy ââ¬â Major, Minor Types of Alternative Energy and Quasi Clean Energyâ⬠. Greenworldinvestor.com. 2011. Web. greenworldinvestor.com/2011/04/12/types-of-renewable-energy-majorminor-types-of-alternative-energy-and-quasi-clean-energy/ Sawyer, Winfred. ââ¬Å"Advantages And Disadvantages Of Renewable Energy Sourcesâ⬠. Freeenergydays.com. 2006. Web. freeenergydays.com/free_energy/advantages-and-disadvantages-of-renewable-energy-sources/ The NEED Project. ââ¬Å"Hydropowerâ⬠. www.NEED.org. 2011. Web. need.org/needpdf/infobook_activities/SecInfo/HydroS.pdf Weir, Clare. ââ¬Å"The answer to woes is blowing in the windâ⬠. Belfast Telegraph. 2011. Web. belfasttelegraph.co.uk/business/business-news/the-answer-to-woes-is-blowing-in-the-wind-16087259.html West, Larry. ââ¬Å"Top 7 Renewable Energy Sourcesâ⬠. About.com. 2011. Web. http://environment.about.com/od/renewableenergy/tp/renew_energy.htm
Thursday, March 5, 2020
Biography and Facts About Elizabeth Bowes-Lyon
Biography and Facts About Elizabeth Bowes-Lyon Elizabeth Bowes-Lyonà was the daughter of the Scottish Lord Glamis, who became the 14th Earl of Strathmore and Kinghorne, Elizabeth was educated at home. She was a descendant of the Scottish King, Robert the Bruce. Brought up to duty, she worked to nurse troops in World War I when her home was used as a hospital for the wounded. Life and Marriage In 1923, Elizabeth married the second son of George V, the shy and stuttering Prince Albert, after turning down his first two proposals. She was the first commoner to legally marry into the royal family in several centuries. Their daughters, Elizabeth and Margaret, were born in 1926 and 1930, respectively. In 1936, Alberts brother, King Edward VIII, abdicated to marry Wallis Simpson, a divorcee, and Albert was crowned King of Great Britain and Ireland as George VI. Elizabeth thus became queen consort and they were crowned May 12, 1937. Neither had expected these roles and while they fulfilled them dutifully, Elizabeth never forgave the Duke and Duchess of Windsor, the titles of Edward and his wife after the abdication and their marriage. When Elizabeth refused to leave England during the London Blitz in World War II, even enduring the bombing of Buckingham Palace, where she was residing with the king, her spirit was an inspiration to many who continued to hold her in high regard until her death. George VI died in 1952, and Elizabeth became known as the Queen Mother, or fondly as the Queen Mum, as their daughter, Elizabeth, became Queen Elizabeth II. Elizabeth as Queen Mother remained in the public eye, making appearances and remaining popular even through the many royal scandals, including her daughter Margarets romance with a divorced commoner, Capt. Peter Townsend, and her grandsons rocky marriages to Princess Diana and Sarah Ferguson. She was especially close to her grandson, Prince Charles, born in 1948. Death In her later years, Elizabeth was plagued with ill health, though she continued to appear in public regularly until a few months before her death. In March of 2002, Elizabeth, the Queen Mum, died in her sleep at age 101, just weeks after her daughter, Princess Margaret, died at age 71. Her familys home, Glamis Castle, is perhaps most famous as the home of Macbeth of Shakespearean fame. Source: The Queen Mother: Chronicle of a Remarkable Life 1900-2000. 2000. Massingbred, Hugh. Her Majesty Queen Elizabeth the Queen Mother: Woman of the Century. 1999. Cornforth, John. Queen Elizabeth: The Queen Mother at Clarence House. 1999. De-la-Noy, Michael. The Queen Behind the Throne. 1994. Pimlott, Ben. The Queen: A Biography of Elizabeth II. 1997. Strober, Deborah Hart and Gerald S. Strober. The Monarchy: An Oral Biography of Elizabeth II. 2002. Botham, Noel. Margaret: The Last Real Princess. 2002.
Monday, February 17, 2020
Youth Justice System in England and Wales in Comparison with another Essay
Youth Justice System in England and Wales in Comparison with another Country - Essay Example The three stages of juvenile justice system include pre-trial, trial, and post-trial. The pre-trial stage includes those activities that occur in between the time when a crime gets reported and the young criminal is taken for trial in the court. The trial is the stage when the proceedings occur within a court in order to judge the treatments for the young offender depending on his crime. Once the treatment/judgment against him/her is declared the treatment of the offender is represented by the post-trial stage. In the whole process, professionals including police, prosecutor, as well as judges have a significant role to play since it is their powers that together decide and implement the treatment of the young offender (Swain, 2009, p.230). Earlier it was thought that justice systems do not have much impact on the behavior of the offenders and that such individuals cannot be corrected. However, in England and Wales, the youth justice system was more strictly taken concern of after th e incident of a murder of a young child by another two 10 yearsââ¬â¢ old boys. This incident had shaken the world and since then the justice systems in these countries had become more strict and severe to take measures against youth crimes. Establishment of Youth Justice Board was considered intending to set up proper leaders and teams as well as standards to focus on the youth crimes occurring in these countries and thereby implementing measures to treat such offenders correcting them and bringing them back into the society (Graham & Moore, 2006, pp.65-66). The present study focuses on the youth justice system prevailing in England and Wales and comparing the system with that of another country that has been considered to be Netherlands for the particular study and discussing the extent to which each of these countries takes into account the welfare and rights of the child. The Youth Justice Board: The Youth Justice Board (YJB) in England and Wales represents a public body that is in charge of the justice system in England and Wales. The Secretary of State for Justice appoints the members of the body. The purpose of this board is to prevent criminal activities by young individuals thus making sure that the offenders are safely and securely taken care of while their trials proceed. The reasons for the youth being involved in crimes are tried to be analyzed by this board such that they can be prevented from repeating the activities in the future (About the Youth Justice Board, 2012). A survey conducted by the British Crime Survey (BCS) reveals that according to the perceptions of the society or the community, young offenders need to be rehabilitated in order to correct them of their crimes that they have committed. Around 45 percent of the respondents of the study by BCS had supported the rehabilitation program and believed that the Youth Justice System should have their focus on such programs. However other respondents had their belief that the young delinq uents were treated very leniently by the justice system (Youth Justice Statistics 2010/11, 2012). To understand these issues, the justice system, the records of criminal activities, and the respective treatments in England and Wales would be relevant for understanding through a detailed study that follows in the further sections of the report. Youth Justice System in England and Wales: The Youth Justice Board (YJB) is in charge of the youth justice system in England and Wales. The board has the responsibility of managing the young offenders as well as determining ways through which such offenders may be prevented from performing crimes in future. Of a total ?800 million that is considered as the cost of
Monday, February 3, 2020
Diacyl Glycerol in the Context of Diabetic Nephropathy Assignment
Diacyl Glycerol in the Context of Diabetic Nephropathy - Assignment Example Diabetic nephropathy is a serious diabetes complication characterized purposely by albuminuria and glomerular hyperfiltration and it is one of the most known common sources of a final stage of renal failure, especially in the western world. It is characterized by a massive growth of the extracellular matrix with coagulation of the tabular basement covering and the glomerular. A buildup of extracellular matrix proteins such a laminin, fibronectin, and collagen are known to cause mesangial enlargement making most of the kidney cellular elements targets of hyperglycemic damage. During hyperglycemia, the levels of glucose in the proximal tubular cells are increased causing DAG levels to increase (Tomino 16). The DAG accumulation leads to the activation of PKC and overproduction of TGF-Ã ² which may be a negative feedback of intracellular cell accumulation. Through the de novo amalgamation of diacylglycerol (DAG) protein kinase C is activated which leads to further activation of other intracellular indicators in transduction systems like the extracellular regulated kinase (ERK). The activation of the three pathways: DAG, ERK and PKC are one of the most significant molecular mechanisms of the progression and development of diabetic nephropathy (Becker, Bilezikian, Bremner et al 957). By inhibiting the three paths there was a prevention to the development of glomerular dysfunction in diabetic people which proved the hypothesis that the three paths are important in diabetic nephropathy. Thiazolidinedione compounds inhibited PKC activation by ensuring that the DAG kinase was activated which prevented albuminuria, glomerular hyperfiltration and the excessive manufacturing of extracellular matrix proteins for Type 1 diabetes. Researchers have confirmed the signing of the activation of the three pathways in the growth of glomerular dysfunction in diabetic nephropathy. Pathophysiology due to a problem with the signaling pathway: DAG is an upstream deactivator of PKC, a pathway responsible for the excessive formation of urine in the kidneys. When DAG has activated it ensures control of urine in the urine bladder by relaxing its muscles regularly.Ã
Subscribe to:
Posts (Atom)